Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians.

ABSTRACT:

Aims

The current meta-analysis tested independent and composite associations of three commonly studied alcohol metabolism alleles with alcohol use disorder (AUD) within East Asians as well as characterized potential moderating factors in these associations.

Methods

For meta-analysis, 32 articles were selected that investigated ALDH2 (n = 17,755), ADH1B (n = 13,591) and ADH1C (n = 4,093) associations with AUD in East Asians.

Results and conclusions

All three variants were associated with AUD across allelic and genotypic models: ALDH2, ORs = 0.25, P < 0.001; ADH1B, ORs = 0.22-0.49, P < 0.001; ADH1C, ORs = 0.26-0.46, P < 0.001. Composite analyses suggested genetic associations did not differ across ALDH2*2 and ADH1B*2, correcting for multiple comparisons. Moderation anal

SUBMITTER: Zaso MJ 

PROVIDER: S-EPMC6516434 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature