Optical imaging of voltage and calcium in isolated hearts: Linking spatiotemporal heterogeneities and ventricular fibrillation initiation.

ABSTRACT:

Background

Alternans have been associated with the development of ventricular fibrillation and its control has been proposed as antiarrhythmic strategy. However, cardiac arrhythmias are a spatiotemporal phenomenon in which multiple factors are involved (e.g. calcium and voltage spatial alternans or heterogeneous conduction velocity) and how an antiarrhythmic drug modifies these factors is poorly understood.

Objective

The objective of the present study is to evaluate the relation between spatial electrophysiological properties (i.e. spatial discordant alternans and conduction velocity) and the induction of ventricular fibrillation (VF) when a calcium blocker is applied.

Methods

The mechanisms of initiation of VF were studied by simultaneous epicardial voltage and calci

SUBMITTER: Hernandez-Romero I 

PROVIDER: S-EPMC6516663 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature