Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.

ABSTRACT:

Background

A range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related.

Methods

This multi-centre study includes 8754 participants: 2212 people with a psychotic disorder, 1487 unaffected relatives of probands, and 5055 healthy controls. We investigated cognition [digit span (N = 3127), block design (N = 5491), and the Rey Auditory Verbal Learning Test (N = 3543)], electrophysiology [P300 amplitude and latency (N = 1102)], and neuroanatomy [lateral ventricular volume (N = 1721)]. We used linear regression to assess the interrelationships between endophenotypes.

Results

The P300 amplitude and latency were not associated (regression coef. -0.06, 95% CI -0.12 to 0.01, p = 0.060), and P300 amplitude

SUBMITTER: Blakey R 

PROVIDER: S-EPMC6516747 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature