Synthesis and Characterization of a Fluorinated S-Nitrosothiol as the Nitric Oxide Donor for Fluoropolymer-Based Biomedical Device Applications.

ABSTRACT: Fluorinated polymers are widely used as biomaterials in various biomedical implant and device applications. However, thrombogenicity, surface-induced inflammation, and risk of microbial infection remain key issues that can limit their use. In this work, we describe the first nitric oxide (NO) releasing fluorinated polymer, in which a new fluorinated NO donor, S-nitroso-N-pentafluoropropionylpenicillamine (C₂F₅-SNAP), is incorporated within the polyvinylidene fluoride (PVDF) tubing. The synthesis, decomposition kinetics, and NO-release characteristics of the C₂F₅-SNAP species are described in detail. Then, using a simple solvent swelling method, we demonstrate that C₂F₅-SNAP can readily be doped into PVDF tubing

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6516761 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature