Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.

ABSTRACT:

Background

The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart, a role for primary cilia in adult heart has not been reported. This, coupled with the fact that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a disorder with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a role in disease-related remodeling.

Methods

Histological analysis of cardiac tissues from C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluat

SUBMITTER: Villalobos E 

PROVIDER: S-EPMC6517085 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature