IL-7R blockade reduces post-myocardial infarction-induced atherosclerotic plaque inflammation in ApoE^-/- mice.

ABSTRACT: Modulating inflammation by targeting IL-1β reduces recurrent athero-thrombotic cardiovascular events without lipid lowering. This presents an opportunity to explore other pathways associated with the IL-1β signaling cascade to modulate the inflammatory response post-myocardial infarction (MI). IL-7 is a mediator of the inflammatory pathway involved in monocyte trafficking into atherosclerotic plaques and levels of IL-7 have been shown to be elevated in patients with acute MI. Recurrent athero-thrombotic events are believed to be mediated in part by index MI-induced exacerbation of inflammation in atherosclerotic plaques. The objective of the study was to assess the feasibility of IL-7R blockade to modulate atherosclerotic plaque inflammation following acute MI in ApoE^-/- mice. M

SUBMITTER: Mihailovic PM 

PROVIDER: S-EPMC6517313 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature