Rubidium-82 PET imaging is feasible in a rat myocardial infarction model.

ABSTRACT:

Background

Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 (⁸²Rb) in a small-animal scanner using a rat myocardial infarct model.

Methods

18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. ⁸²Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct s

SUBMITTER: Ghotbi AA 

PROVIDER: S-EPMC6517336 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature