Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?

ABSTRACT:

Introduction

The retina is a potential source of noninvasive vascular biomarkers for Alzheimer's disease (AD). We assessed retinal microvasculature in well-characterized AD cases, taking ophthalmological confounders into account.

Methods

We included 48 amyloid-positive AD patients and 38 amyloid-negative cognitively normal control subjects. All participants underwent ophthalmological screening to exclude interfering ocular disease. Using a multimodal approach, we measured retinal vascular parameters, choroidal thickness, macular vascular density, and foveal avascular zone size.

Results

We found no disease effects on retinal vascular measures (all β's < |0.15|, all P > .2), adjusted for confounders. Venular tortuosity was inversely associated with Fazekas score

SUBMITTER: den Haan J 

PROVIDER: S-EPMC6517376 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature