A biological function based biomarker panel optimization process.

ABSTRACT: Implementation of multi-gene biomarker panels identified from high throughput data, including microarray or next generation sequencing, need to be adapted to a platform suitable in a clinical setting such as quantitative polymerase chain reaction. However, technical challenges when transitioning from one measurement platform to another, such as inconsistent measurement results can affect panel development. We describe a process to overcome the challenges by replacing poor performing genes during platform transition and reducing the number of features without impacting classification performance. This approach assumes that a diagnostic panel reflects the effect of dysregulated biological processes associated with a disease, and genes involved in the same biological processes and coordinatel

SUBMITTER: Lee MY 

PROVIDER: S-EPMC6517383 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature