Features of the cervicovaginal microenvironment drive cancer biomarker signatures in patients across cervical carcinogenesis.

ABSTRACT: Persistent human papillomavirus (HPV) infection is the vital factor driving cervical carcinogenesis; however, other features of the local cervicovaginal microenvironment (CVM) may play a critical role in development of precancerous cervical dysplasia and progression to invasive cervical carcinoma (ICC). Here we investigated relationships between locally secreted cancer biomarkers and features of the local CVM to better understand the complex interplay between host, virus and vaginal microbiota (VMB). We enrolled women with ICC, high- and low-grade squamous intraepithelial lesions, as well as, HPV-positive and healthy HPV-negative controls. A broad range of cancer biomarkers was present in the local CVM and specifically elevated in ICC patients. The majority of cancer biomarkers were positi

SUBMITTER: Laniewski P 

PROVIDER: S-EPMC6517407 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature