Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.

ABSTRACT:

Background

Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin-angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS.

Methods

In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days-18 years), 26 adults (18-65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubat

SUBMITTER: Schouten LR 

PROVIDER: S-EPMC6517452 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature