Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients.

ABSTRACT: Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4⁺ cells in normal and pathological conditions, which exerts its anti-inflammatory and immunomodulatory actions through VPAC receptors, VPAC₁ and VPAC₂. Only a decrease in the expression of VPAC₁ mRNA on Th cells upon activation has been reported. Thus, the deepening in the knowledge of the behavior of these receptors may contribute to the design of new therapies based on their activation and/or blockade. In this study, we describe the expression pattern, cellular location and functional role of VIP receptors during the activation of human Th cells in healthy conditions and in early arthritis (EA). The protein expression pattern of VPAC₁ did not change with the ac

SUBMITTER: Villanueva-Romero R 

PROVIDER: S-EPMC6517580 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature