18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques.

ABSTRACT: BACKGROUND:There is currently no consensus on the methodology for quantification of 18F-FDG uptake in inflammation in atherosclerosis. In this study, we explore different methods for quantification of 18F-FDG uptake in carotid atherosclerotic plaques and correlate the uptake values to histological assessments of inflammation. METHODS AND RESULTS:Forty-four patients with atherosclerotic stenosis ≥70% of the internal carotid artery underwent 18F-FDG PET/CT. Maximum standardized uptake values (SUVmax) from all plaque-containing slices were collected. SUVmax for the single highest and the mean of multiple slices with and without blood background correction (by subtraction (cSUV) or by division (target-to-background ratio (TBR)) were calculated. Following endarterectomy 30 plaques were assessed

SUBMITTER: Johnsrud K 

PROVIDER: S-EPMC6517604 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature