Resistance Gene-Directed Genome Mining of 50 Aspergillus Species.

ABSTRACT: Fungal secondary metabolites are a rich source of valuable natural products, and genome sequencing has revealed a proliferation of predicted biosynthetic gene clusters in the genomes. However, it is currently an unfeasible task to characterize all biosynthetic gene clusters and to identify possible uses of the compounds. Therefore, a rational approach is needed to identify a short list of gene clusters responsible for producing valuable compounds. To this end, several bioactive clusters include a resistance gene, which is a paralog of the target gene inhibited by the compound. This mechanism can be used to identify these clusters. We have developed the FRIGG (fungal resistance gene-directed genome mining) pipeline for identifying this type of biosynthetic gene cluster based on homology pat

SUBMITTER: Kjærbolling I 

PROVIDER: S-EPMC6517689 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature