Social-Stress-Responsive Microbiota Induces Stimulation of Self-Reactive Effector T Helper Cells.

ABSTRACT: Stressful life events are considered a risk factor for autoimmune disorders, though the mechanisms are unclear. Here we demonstrate that chronic social stress induces virulence-associated transcriptional patterns in the murine gut microbiota. The stress-influenced microbiota increased the presence of effector T helper cells in the mesenteric lymph nodes, including myelin-autoreactive cells. Inhibition of the bacterial quorum sensor QseC, which is also responsive to norepinephrine, diminished the presence of effector T helper cells and bacteria such as Acinetobacter in the mesenteric lymph nodes, without remarkably affecting the gut microbial composition. Together, our results delineate a model in which the immune reaction to stress-responsive microbiota may compromise tolerance to self and

SUBMITTER: Werbner M 

PROVIDER: S-EPMC6517692 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature