Protective Effects of Ammannia baccifera Against CCl₄-Induced Oxidative Stress in Rats.

ABSTRACT: Ammannia baccifera Linn. is commonly used as a traditional medicine in India and China. The antioxidant potential of an ethanolic extract of A. baccifera (EEAB; 250 mg/kg and 500 mg/kg) was evaluated against CCL₄-induced toxicity in rats. Antioxidant activity was assessed by measuring the enzymatic and non-enzymatic antioxidants. Phytochemical constituents of EEAB were also analyzed by using UHPLC-QTOF-MS. EEAB treatment markedly reduced CCl₄ effects on lipid peroxidation, cholesterol, triacylglycerides, and protein carbonyls. It increased the levels of phospholipids, total sulfhydryl, and antioxidant enzymes, which were reduced by CCl₄ intoxication. Treatment with EEAB significantly alleviated the CCl₄ effect on non-enzymatic antio

SUBMITTER: Goodla L 

PROVIDER: S-EPMC6517918 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature