H. pylori Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans.

ABSTRACT: Changes in the intestinal microbial community and some metabolic disturbances, including obesity and type2 diabetes, are related. Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis. Microbiota have been linked to incretin secretion. Antibiotic use causes changes in microbial diversity and composition. Our aim was to evaluate the relationship between microbiota changes and GLP-1 secretion. A prospective case-control study with a Helicobacter pylori-positive patient model involving subjects under eradication therapy (omeprazole, clarithromycin, and amoxicillin). Forty patients with H. pylori infection and 20 matched participants, but negative for H. pylori antigen. Patients were evaluated before and two months after treatment. We analyzed anthropometric measur

SUBMITTER: Cornejo-Pareja I 

PROVIDER: S-EPMC6517938 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature