Celiac Disease Prevalence is Increased in Primary Sjogren's Syndrome and Diffuse Systemic Sclerosis: Lessons from a Large Multi-Center Study.

ABSTRACT: Association of celiac disease (CD) with systemic autoimmune diseases (ADs) remains controversial. Awareness of CD in these patients is important to prevent complications, including lymphoproliferative disorders. We evaluated previously diagnosed CD prevalence in systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS) and systemic sclerosis (SSc) patients in comparison to 14,298 matched controls. All patients were screened for subclinical CD. Data from 1458 unselected consecutive SLE (580), pSS (354) and SSc (524) patients were collected. Previously biopsy-proven CD diagnosis and both CD- and AD-specific features were registered. All patients without previous CD were tested for IgA transglutaminase (TG). Anti-endomysium were tested in positive/borderline IgA TG. Duodenal biopsy

SUBMITTER: Bartoloni E 

PROVIDER: S-EPMC6517955 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature