ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study.

ABSTRACT:

Aims/hypothesis

ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes.

Methods

This study included 5176 participants from the Rotterdam Study, a prospective population-based cohort study. Participants were free of diabetes at baseline and followed up for more than 20 years. Cox proportional hazards models were used to examine the association of ADAMTS13 activity and VWF antigen with incident diabetes.

Results

ADAMTS13 activity was associated with an increased risk of incident diabetes (HR 1.17 [95% CI 1.08, 1.27]) after adjustm

SUBMITTER: de Vries PS 

PROVIDER: S-EPMC6518068 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature