Investigation of gene-diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study.

ABSTRACT:

Aims/hypothesis

The gut incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have a major role in the pathophysiology of type 2 diabetes. Specific genetic and dietary factors have been found to influence the release and action of incretins. We examined the effect of interactions between seven incretin-related genetic variants in GIPR, KCNQ1, TCF7L2 and WFS1 and dietary components (whey-containing dairy, cereal fibre, coffee and olive oil) on the risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study.

Methods

The current case-cohort study included 8086 incident type 2 diabetes cases and a representative subcohort of 11,035 participants (median follow-up: 12.5 years). Pre

SUBMITTER: InterAct Consortium 

PROVIDER: S-EPMC6518069 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature