Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis.

ABSTRACT:

Aims/hypothesis

Pre-eclampsia is a pregnancy-specific multisystem disorder and a state of physiological insulin resistance. Our aim was to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future risk of diabetes.

Methods

We conducted a systematic review and meta-analysis of studies that evaluated diabetes in women with and without pre-eclampsia. We performed a systematic search of MEDLINE and EMBASE to identify relevant studies. Independent double data extractions were conducted by four reviewers. Random-effects meta-analysis was used to estimate the risk of future diabetes following pre-eclampsia.

Results

A total of 21 studies were identified with more than 2.8 million women, including more than 72,500 women with pre

SUBMITTER: Wu P 

PROVIDER: S-EPMC6518071 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature