Immunogenicity of human embryonic stem cell-derived beta cells.

ABSTRACT:

Aims/hypothesis

To overcome the donor shortage in the treatment of advanced type 1 diabetes by islet transplantation, human embryonic stem cells (hESCs) show great potential as an unlimited alternative source of beta cells. hESCs may have immune privileged properties and it is important to determine whether these properties are preserved in hESC-derived cells.

Methods

We comprehensively investigated interactions of both innate and adaptive auto- and allo-immunity with hESC-derived pancreatic progenitor cells and hESC-derived endocrine cells, retrieved after in-vivo differentiation in capsules in the subcutis of mice.

Results

We found that hESC-derived pancreatic endodermal cells expressed relatively low levels of HLA endorsing protection from specific immune responses

SUBMITTER: van der Torren CR 

PROVIDER: S-EPMC6518073 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature