Estimation of individual beneficial and adverse effects of intensive glucose control for patients with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes.

Methods

We performed a post hoc analysis of the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial, a randomised controlled trial evaluating standard vs intensive glucose control (HbA_1c target ≤6.5% [48 mmol/mol]). In 11,140 participants, we estimated the individual 5 year absolute risk reduction (ARR) for the composite outcome of major micro- and macrovascular events and absolute risk increase (ARI) for severe hypoglycaemia for intensi

SUBMITTER: van der Leeuw J 

PROVIDER: S-EPMC6518074 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature