Insulitis in human diabetes: a histological evaluation of donor pancreases.

ABSTRACT:

Aims/hypothesis

According to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45⁺ cells are found within the parenchyma or in the islet-exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabetes fulfilling these criteria with reference to non-diabetic and type 1 diabetic individuals.

Methods

Insulitis was determined by examining CD45⁺ cells in the pancreases of 50, 13 and 44 organ donors with type 2 diabetes, type 1 diabetes and no diabetes, respectively. CD3⁺ cells (T cells) infiltrating the islets were evaluated in insulitic donors. In insulitic donors with type 2 diabetes, the pancreases were characterised accordin

SUBMITTER: Lundberg M 

PROVIDER: S-EPMC6518093 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature