Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca²⁺ channels in a Ca_Vβ-dependent manner.

ABSTRACT: Voltage-gated Ca²⁺ (Ca_V) channels couple membrane depolarization to Ca²⁺ influx, triggering a range of Ca²⁺-dependent cellular processes. Ca_V channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function of Ca_V channels. GPCR-dependent mechanisms that downregulate Ca_V channel expression levels are observed in many neurons but are, by comparison, less studied. Here we show that the growth hormone secretagogue receptor type 1a (GHSR), a GPCR, can inhibit the forwa

SUBMITTER: Mustafa ER 

PROVIDER: S-EPMC6518300 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature