Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria.

ABSTRACT:

Aims/hypothesis

Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown.

Methods

In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drug

SUBMITTER: Maltese G 

PROVIDER: S-EPMC6518370 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature