Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables.

ABSTRACT:

Aims/hypothesis

Beta cell function in type 1 diabetes is commonly assessed as the average plasma C-peptide concentration over 2 h following a mixed-meal test (CP_AVE). Monitoring of disease progression and response to disease-modifying therapy would benefit from a simpler, more convenient and less costly measure. Therefore, we determined whether CP_AVE could be reliably estimated from routine clinical variables.

Methods

Clinical and fasting biochemical data from eight randomised therapy trials involving participants with recently diagnosed type 1 diabetes were used to develop and validate linear models to estimate CP_AVE and to test their accuracy in estimating loss of beta cell function and response to immune therapy.

Results

A model bas

SUBMITTER: Wentworth JM 

PROVIDER: S-EPMC6518395 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature