Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation.

ABSTRACT:

Background

Given recent challenges in developing new treatments for Alzheimer dementia (AD), it is vital to explore alternate treatment targets, such as neuromodulation for circuit dysfunction. We previously reported an exploratory Phase IIb double-blind trial of deep brain stimulation targeting the fornix (DBS-f) in mild AD (the ADvance trial). We reported safety but no clinical benefits of DBS-f versus the delayed-on (sham) treatment in 42 participants after one year. However, secondary post hoc analyses of the one-year data suggested a possible DBS-f benefit for participants≥65 years.

Objective

To examine the long-term safety and clinical effects of sustained and delayed-on DBS-f treatment of mild AD after two years.

Methods

42 participants underwent implantation o

SUBMITTER: Leoutsakos JS 

PROVIDER: S-EPMC6518401 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature