Chronic prostatitis alters the prostatic microenvironment and accelerates preneoplastic lesions in C57BL/6 mice.

ABSTRACT:

Background

Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenvironment and gene mutation in C57BL/6 mice.

Methods

Immune and bacterial prostatitis mouse models were created through abdominal subcutaneous injection of rat prostate extract protein immunization (EAP group) or transurethral instillation of uropathogenic E. coli 1677 (E. coli group). Prostate histology, serum cytokine level, and genome-wide exome (GWE) sequences were examined 1, 3, and 6 months after immunization or injection.

Result

In the EAP and E. coli groups, immune cell infiltrations were observed in the first and last months of the entire experimen

SUBMITTER: Gao Y 

PROVIDER: S-EPMC6518623 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature