The role of ^mSEPT9 in screening, diagnosis, and recurrence monitoring of colorectal cancer.

ABSTRACT:

Background

The application of circulating, cell-free, methylated Septin9 (^mSEPT9) DNA in screening and recurrence monitoring is highly promising. CpG island methylator phenotype (CIMP) is associated with microsatellite instability (MSI). The present study was performed to determine the diagnostic accuracy of ^mSEPT9 for colorectal cancer (CRC) and to evaluate its utility in CRC screening and recurrence monitoring.

Methods

For screening and diagnosis of CRC, peripheral ^mSEPT9 detection and fecal occult blood test (FOBT) were performed in 650 subjects, then the level of CEA, CA19-9 and CA724 was quantified in 173 subjects. Clinicopathological parameters and mismatch repair protein were detected among subjects with CRC. For recurrence monitoring

SUBMITTER: Sun J 

PROVIDER: S-EPMC6518628 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature