The evolution of S100A7: an unusual gene expansion in Myotis bats.

ABSTRACT:

Background

The S100A7 gene, also called psoriasin, was first described as an upregulated protein in psoriatic skin. For the past years, the importance of this protein as a key effector of innate immunity has been clearly established, not only due to its importance protecting against bacteria skin insult in humans, but also because of its important role in amplifying inflammatory processes. Given the importance of S100A7 in host defense, S100A7 genes have been mostly studied in humans. Here we provide a detailed analysis of the evolution of the gene family encoding for the S100A7 protein in mammals.

Results

Examination of several mammalian genomes revealed an unexpected variation in the copy number of S100A7. Among the most representative mammalian groups, we report that mult

SUBMITTER: Agueda-Pinto A 

PROVIDER: S-EPMC6518696 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature