Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study.

ABSTRACT:

Background

Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in the healthy general population may reveal early disease mechanisms underlying low-grade impairment of both organs as well as the possibility for intervention. Our aim was to identify an early stage of low-grade impairments in both the brain and the kidneys in the general population.

Methods

This investigation was a population-based cross-sectional study that included 1627 participant

SUBMITTER: Smabrekke S 

PROVIDER: S-EPMC6518698 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature