IL1B polymorphism is associated with essential tremor in Chinese population.

ABSTRACT:

Background

The aim of the study was to investigate the genetic risk factors of essential tremor (ET) in Chinese Population.

Methods

A total of 225 ET patients (25 ET patients also had restless legs syndrome (RLS) and were excluded from final analysis) and 229 controls were recruited. The diagnosis of ET was based on the Consensus Statement of the Movement Disorders Society on tremor. Polymerase chain reaction (PCR) and sequencing were used to detect 12 single nucleotide polymorphisms (SNPs) in seven candidate genes for RLS (HMOX1, HMOX2, VDR, IL17A, IL1B, NOS1 and ADH1B).

Results

We found that one SNP was associated with the risk of ET in Chinese population after adjusting for age and gender: rs1143633 of IL1B (odds ratio [OR] =2.57, p = 0.003, recessive model), and t

SUBMITTER: Chen J 

PROVIDER: S-EPMC6518722 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature