Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.

ABSTRACT:

Background and objective

This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF).

Methods

A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Results were evaluated against readouts from lung function tests.

Results

Normalized vessel volume expressed as a percentage of total lung volume was moderately correlated with functional indices on univariable linear regression analysis: forced vital capacity (R² =

SUBMITTER: Jacob J 

PROVIDER: S-EPMC6519024 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature