Cardiac status of perinatally HIV-infected children: assessing combination antiretroviral regimens in observational studies.

ABSTRACT:

Objective

To evaluate potential adverse associations of individual antiretroviral medications used in combination antiretroviral therapy regimens on cardiac structure and function in youth with perinatally-acquired HIV infection (PHIV).

Design

PHIV youth (N = 325) enrolled in a prospective multisite cohort study had a single echocardiogram at age 7-16 years to evaluate cardiac function and structure.

Methods

We applied several statistical approaches to evaluate associations between use of 18 individual antiretroviral medications with Z-scores for 11 measures of left ventricular function and structure. These included simultaneously evaluating all antiretroviral medications in adjusted linear regression models controlling for the false discovery rate (FDR), applying hie

SUBMITTER: Williams PL 

PROVIDER: S-EPMC6519135 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature