Maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda.

ABSTRACT: Aflatoxins are toxic metabolites of Aspergillus moulds and are widespread in the food supply, particularly in low- and middle-income countries. Both in utero and infant exposure to aflatoxin B₁ (AFB₁ ) have been linked to poor child growth and development. The objective of this prospective cohort study was to investigate the association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes, primarily lower birth weight, in a sample of 220 mother-infant pairs in Mukono district, Uganda. Maternal aflatoxin exposure was assessed by measuring the serum concentration of AFB₁ -lysine (AFB-Lys) adduct at 17.8 ± 3.5 (mean ± SD)-week gestation using high-performance liquid chromatography. Anthropometry and birth outcome characteristics were

SUBMITTER: Lauer JM 

PROVIDER: S-EPMC6519241 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature