Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.

ABSTRACT: Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17% overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.

SUBMITTER: Brown CA 

PROVIDER: S-EPMC6519258 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature