Synaptic Failure Differentially Affects Pattern Formation in Heterogenous Networks.

ABSTRACT: The communication of neurons is primarily maintained by synapses, which play a crucial role in the functioning of the nervous system. Therefore, synaptic failure may critically impair information processing in the brain and may underlie many neurodegenerative diseases. A number of studies have suggested that synaptic failure may preferentially target neurons with high connectivity (i.e., network hubs). As a result, the activity of these highly connected neurons can be significantly affected. It has been speculated that anesthetics regulate conscious state by affecting synaptic transmission at these network hubs and subsequently reducing overall coherence in the network activity. In addition, hubs in cortical networks are shown to be more vulnerable to amyloid deposition because of their hi

SUBMITTER: Budak M 

PROVIDER: S-EPMC6519395 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature