In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

ABSTRACT: Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

SUBMITTER: Nash EE 

PROVIDER: S-EPMC6519449 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature