Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0).

ABSTRACT: The PANTHER classification system ( http://www.pantherdb.org ) is a comprehensive system that combines genomes, gene function classifications, pathways and statistical analysis tools to enable biologists to analyze large-scale genome-wide experimental data. The current system (PANTHER v.14.0) covers 131 complete genomes organized into gene families and subfamilies; evolutionary relationships between genes are represented in phylogenetic trees, multiple sequence alignments and statistical models (hidden Markov models (HMMs)). The families and subfamilies are annotated with Gene Ontology (GO) terms, and sequences are assigned to PANTHER pathways. A suite of tools has been built to allow users to browse and query gene functions and analyze large-scale experimental data with a number of statis

SUBMITTER: Mi H 

PROVIDER: S-EPMC6519457 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature