Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction.

ABSTRACT: Chronic caloric restriction (CR) without malnutrition is known to affect different cellular processes such as stem cell function, cell senescence, inflammation, and metabolism. Despite the differences in the implementation of CR, the reduction of calories produces a widespread beneficial effect in noncommunicable chronic diseases, which can be explained by improvements in immuno-metabolic adaptation. Cellular adaptation that occurs in response to dietary patterns can be explained by alterations in epigenetic mechanisms such as DNA methylation, histone modifications, and microRNA. In this review, we define these modifications and systematically summarize the current evidence related to CR and the epigenome. We then explain the significance of genome-wide epigenetic modifications in the cont

SUBMITTER: Hernandez-Saavedra D 

PROVIDER: S-EPMC6520046 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature