Dynamic Cortical Connectivity during General Anesthesia in Surgical Patients.

ABSTRACT:

Background

Functional connectivity across the cortex has been posited to be important for consciousness and anesthesia, but functional connectivity patterns during the course of surgery and general anesthesia are unknown. The authors tested the hypothesis that disrupted cortical connectivity patterns would correlate with surgical anesthesia.

Methods

Surgical patients (n = 53) were recruited for study participation. Whole-scalp (16-channel) wireless electroencephalographic data were prospectively collected throughout the perioperative period. Functional connectivity was assessed using weighted phase lag index. During anesthetic maintenance, the temporal dynamics of connectivity states were characterized via Markov chain analysis, and state transition probabilities were quanti

SUBMITTER: Vlisides PE 

PROVIDER: S-EPMC6520139 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature