Nanoparticle physicochemical properties determine the activation of intracellular complement.

ABSTRACT: The complement system plays an essential role in both innate and adaptive immunity. The traditional understanding of this system comes from studies investigating complement proteins produced by the liver and present in plasma to "complement" the immune cell-mediated response to invading pathogens. Recently, it has been reported that immune cells including, but not limited to, T-cells and monocytes, express complement proteins. This complement is referred to as intracellular (IC) and implicated in the regulation of T-cell activation. The mechanisms and the structure-activity relationship between nanomaterials and IC, however, are currently unknown. Herein, we describe a structure-activity relationship study demonstrating that under in vitro conditions, only polymeric materials with cationic

SUBMITTER: Ilinskaya AN 

PROVIDER: S-EPMC6520145 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature