Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor.

ABSTRACT: Cerebellar degenerative pathology has been identified in tremor patients; however, how the degenerative pathology could contribute to tremor remains unclear. If the cerebellar degenerative pathology can directly drive tremor, one would hypothesize that tremor is likely to occur in the diseases of cerebellar ataxia and follows the disease progression in such disorders. To further test this hypothesis, we studied the occurrence of tremor in different disease stages of classical cerebellar degenerative disorders: spinocerebellar ataxias (SCAs). We further separately analyzed postural tremor and rest tremor, two forms of tremor that both involve the cerebellum. We also explored tremor in different subtypes of SCAs. We found that 18.1% of SCA patients have tremor. Interestingly, SCA patients wi

SUBMITTER: Lai RY 

PROVIDER: S-EPMC6520148 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature