Reconstructed Skin Models Revealed Unexpected Differences in Epidermal African and Caucasian Skin.

ABSTRACT: Clinical observations of both normal and pathological skin have shown that there is a heterogeneity based on the skin origin type. Beside external factors, intrinsic differences in skin cells could be a central element to determine skin types. This study aimed to understand the in vitro behaviour of epidermal cells of African and Caucasian skin types in the context of 3D reconstructed skin. Full-thickness skin models were constructed with site matched human keratinocytes and papillary fibroblasts to investigate potential skin type related differences. We report that reconstructed skin epidermis exhibited remarkable differences regarding stratification and differentiation according to skin types, as demonstrated by histological appearance, gene expression analysed by DNA microarray and quan

SUBMITTER: Girardeau-Hubert S 

PROVIDER: S-EPMC6520399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature