In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System.

ABSTRACT: Helicobacter pylori colonizes about half of humans worldwide, and its presence in the gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric lymphoma, and peptic ulcer disease. H. pylori strains carrying the cag pathogenicity island (cagPAI) are associated with increased risk of disease progression. The cagPAI encodes the Cag type IV secretion system (Cag_T4SS), which delivers the CagA oncoprotein and other effector molecules into human gastric epithelial cells. We visualized structures of native and mutant Cag_T4SS machines on the H. pylori cell envelope by cryoelectron tomography. Individual H. pylori cells contain multiple Cag_T4SS nanomachines, each composed of a wheel-shaped

SUBMITTER: Hu B 

PROVIDER: S-EPMC6520456 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature