D-type potassium channels normalize action potential firing between dorsal and ventral CA1 neurons of the mouse hippocampus.

ABSTRACT: Specific memory processes and neurological disorders can be ascribed to different dorsoventral regions of the hippocampus. Recently, differences in the anatomical and physiological properties between dorsal and ventral hippocampal CA1 neurons were described for both the rat and mouse hippocampus and have greatly contributed to our understanding of these processes. While differences in the subthreshold properties were similar between rat and mouse neurons, differences in action potential output between dorsal and ventral neurons were strikingly less divergent in mouse compared with rat CA1 neurons. Here, we investigate the mechanism underlying the lack of difference in action potential firing between dorsal and ventral CA1 pyramidal neurons in mouse hippocampus. Consistent with rat, we foun

SUBMITTER: Ordemann GJ 

PROVIDER: S-EPMC6520617 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature