The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

ABSTRACT: The process by which salt affects the gastric precancerous process has not been adequately studied in humans. We investigated the effects of salt on gastric inflammation, epithelial damage, the density of Helicobacter pylori infection, and gastric epithelial cell proliferation, all of which may be mediators between salt and gastric precancerous/cancerous lesions. These potential mediators were measured using gastric biopsies as: (a) the density of polymorphonuclear and mononuclear cells (gastric inflammation), (b) mucus depletion (gastric epithelial damage), and (c) the severity of H. pylori infection. Salt intake was measured with spot urine samples (using urinary sodium/creatinine ratios), self-reported frequency of adding salt to food, and as total added salt. The average sodium/creatin

SUBMITTER: Thapa S 

PROVIDER: S-EPMC6520685 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature