Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis.

ABSTRACT: Type 2 diabetes is a complex, heterogeneous, and polygenic disease. Currently, available drugs for treating type 2 diabetes predominantly include sulfonylureas, α-glucosidase inhibitors, and biguanides. However, long-term treatment with these therapeutic drugs is often accompanied by undesirable side effects, which have driven interest in the development of more effective and safer antidiabetic agents. To address the urgent need for new chemical solutions, we focused on the analysis of structurally novel and/or biologically new metabolites produced by insect-associated microbes as they have recently been recognized as a rich source of natural products. Comparative LC/MS-based analysis of Actinomadura sp. RB99, isolated from a fungus-growing termite, led to the identification of the type II

SUBMITTER: Yoon SY 

PROVIDER: S-EPMC6520714 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature