Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment.

ABSTRACT: Variation of maternal gut microbiota may increase the risk of autism spectrum disorders (ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother-child pairs of ASD children and 30 matched mother-child pairs of healthy children. Significant differences were observed in the gut microbiome composition be

SUBMITTER: Li N 

PROVIDER: S-EPMC6520911 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature